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<!-- XBRL Generated with XBRLMark Copyright (C) by RR Donnelley -->
<!-- Based on XBRL 2.1 -->
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    xmlns:xbrli="http://www.xbrl.org/2003/instance"
    xmlns:link="http://www.xbrl.org/2003/linkbase"
    xmlns:xlink="http://www.w3.org/1999/xlink"
    targetNamespace="http://spscommerce.com/20110930"
    xmlns:spsc="http://spscommerce.com/20110930"
    elementFormDefault="qualified"
    attributeFormDefault="unqualified"
    xmlns:xbrldt="http://xbrl.org/2005/xbrldt"
    xmlns:us-types="http://xbrl.sec.gov/us-types/2011-01-31"
    xmlns:nonnum="http://www.xbrl.org/dtr/type/non-numeric"
    xmlns:num="http://www.xbrl.org/dtr/type/numeric">
<annotation>
<appinfo>
<link:roleType roleURI="http://spscommerce.com/role/DocumentAndEntityInformation" id="DocumentAndEntityInformation">
  <link:definition>00 - Document - Document and Entity Information</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/BalanceSheets" id="BalanceSheets">
  <link:definition>01 - Statement - Condensed Consolidated Balance Sheets (Unaudited)</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/BalanceSheetsParenthetical" id="BalanceSheetsParenthetical">
  <link:definition>011 - Statement - Condensed Consolidated Balance Sheets (Unaudited) (Parenthetical)</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/StatementsOfOperations" id="StatementsOfOperations">
  <link:definition>02 - Statement - Condensed Consolidated Statements of Operations (Unaudited)</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/StatementsOfCashFlows" id="StatementsOfCashFlows">
  <link:definition>03 - Statement - Condensed Consolidated Statements of Cash Flows (Unaudited)</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>

<link:roleType roleURI="http://spscommerce.com/role/General" id="General">
  <link:definition>06001 - Disclosure - General</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/AcquisitionOfDirectEdi" id="AcquisitionOfDirectEdi">
  <link:definition>06002 - Disclosure - Acquisition of Direct EDI</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/IntangibleAssets" id="IntangibleAssets">
  <link:definition>06003 - Disclosure - Intangible Assets</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/LineOfCredit" id="LineOfCredit">
  <link:definition>06004 - Disclosure - Line of Credit</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/StockBasedCompensation" id="StockBasedCompensation">
  <link:definition>06005 - Disclosure - Stock-Based Compensation</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/IncomeTaxes" id="IncomeTaxes">
  <link:definition>06006 - Disclosure - Income Taxes</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>
<link:roleType roleURI="http://spscommerce.com/role/NetIncomePerShare" id="NetIncomePerShare">
  <link:definition>06007 - Disclosure - Net Income Per Share</link:definition>
  <link:usedOn>link:presentationLink</link:usedOn>
  <link:usedOn>link:definitionLink</link:usedOn>
  <link:usedOn>link:calculationLink</link:usedOn>
</link:roleType>

<link:linkbaseRef xlink:type="simple" xlink:href="spsc-20110930_cal.xml" xlink:role="http://www.xbrl.org/2003/role/calculationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Calculation Links, all" />
<link:linkbaseRef xlink:type="simple" xlink:href="spsc-20110930_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Presentation Links, all" />
<link:linkbaseRef xlink:type="simple" xlink:href="spsc-20110930_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:title="Label Links, all" />
</appinfo>
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<import namespace="http://www.xbrl.org/dtr/type/non-numeric" schemaLocation="http://www.xbrl.org/dtr/type/nonNumeric-2009-12-16.xsd" />
<import namespace="http://fasb.org/us-types/2011-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2011/elts/us-types-2011-01-31.xsd" />
<import namespace="http://fasb.org/us-gaap/2011-01-31" schemaLocation="http://xbrl.fasb.org/us-gaap/2011/elts/us-gaap-2011-01-31.xsd" />
<import namespace="http://xbrl.sec.gov/dei/2011-01-31" schemaLocation="http://xbrl.sec.gov/dei/2011/dei-2011-01-31.xsd" />
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<element name="ChangeInCarryingValueOfPreferredStockWarrants" id="spsc_ChangeInCarryingValueOfPreferredStockWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" />
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