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<!-- RR Donnelley Xcelerate Taxonomy Schema, based on XBRL 2.1  http://www.rrdonnelley.com/ -->
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<!-- Round: 6 -->
<!-- Creation date: 2017-02-24T15:11:58Z -->
<!-- Copyright (c) 2005-2013 R.R. Donnelley & Sons Company All Rights Reserved. -->
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        <link:definition>164 - Disclosure - Net Income Per Share - Components of Computation of Basic and Diluted Net Income Per Share (Detail)</link:definition>
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      <link:roleType roleURI="http://www.spscommerce.com/taxonomy/role/DisclosureNetIncomePerShareAdditionalInformation" id="DisclosureNetIncomePerShareAdditionalInformation">
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        <link:definition>166 - Disclosure - Retirement Savings Plan - Additional Information (Detail)</link:definition>
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        <link:definition>167 - Disclosure - Related Party Transactions - Additional Information (Detail)</link:definition>
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        <link:definition>168 - Disclosure - Selected Quarterly Financial Data (Unaudited) - Summary of Unaudited Quarterly Statements of Comprehensive Income Data (Detail)</link:definition>
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  <element name="ScheduleOfStockholdersEquityTable" id="spsc_ScheduleOfStockholdersEquityTable" type="xbrli:stringItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrldt:hypercubeItem"/>
  <element name="ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndUnissuedInPeriod" id="spsc_ShareBasedCompensationArrangementByShareBasedPaymentAwardEquityInstrumentsOtherThanOptionsVestedAndUnissuedInPeriod" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="StockIssuedDuringPeriodSharesRestrictedStockAndStockOptionsExercised" id="spsc_StockIssuedDuringPeriodSharesRestrictedStockAndStockOptionsExercised" type="xbrli:sharesItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="StockIssuedDuringPeriodValueRestrictedStockAndStockOptionsExercised" id="spsc_StockIssuedDuringPeriodValueRestrictedStockAndStockOptionsExercised" type="xbrli:monetaryItemType" abstract="false" xbrli:periodType="duration" xbrli:balance="credit" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="SubscriberRelationshipsMember" id="spsc_SubscriberRelationshipsMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="TaxCreditCarryforwardBeginningExpirationYear" id="spsc_TaxCreditCarryforwardBeginningExpirationYear" type="xbrli:gYearItemType" abstract="false" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="TechnologyAndOtherMember" id="spsc_TechnologyAndOtherMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="ToolboxSolutionsIncorporationMember" id="spsc_ToolboxSolutionsIncorporationMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
  <element name="TwoThousandTenMember" id="spsc_TwoThousandTenMember" type="nonnum:domainItemType" abstract="true" xbrli:periodType="duration" nillable="true" substitutionGroup="xbrli:item"/>
</schema>
